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Coluracetam (also known as MKC-231) is a nootropic supplement that improves memory and boosts mental functions. It is also known to alleviate anxiety and depression without affecting serotonin levels.

It works by enhancing high-affinity choline uptake. This increases acetylcholine levels, which are linked to memory and cognition. It also appears to improve AMPA potentiation.

Improves Memory and Concentration

Coluracetam powder europe works like a racetam to improve memory and cognition by increasing the acetylcholine levels. It may also help reduce depression and anxiety and boost energy levels. However, more research is needed to verify these claims.

The main reason why people suffer from cognitive decline is because of low acetylcholine levels. The acetylcholine neurotransmitter is responsible for memory and learning. It is a natural chemical, but Alzheimer’s disease and other brain disorders can cause this system to break down. Coluracetam is known to enhance choline uptake and the enzyme ChAT, which elevates acetylcholine.

The effects of coluracetam on the choline uptake system is the main mechanism behind its nootropic properties. It is also believed to protect NMDA receptors against glutamate cytotoxicity. This makes it an interesting supplement for people with dementia and Alzheimer’s disease. It can also improve long-term and working memory, as well as enhance color and sound perception. It is considered to be a stimulant, but does not produce the same side effects as Ritalin or coffee.

Promotes Neurogenesis

Coluracetam can stimulate neurogenesis and boost hippocampus-derived neural stem cell proliferation in the brain. These stem cells then differentiate into neurons and create memories (5). It is also thought to have a mild stimulant effect, so some users report being able to focus and study more easily while taking this nootropic.

While Piracetam, the original racetam that started the nootropic movement, affects acetylcholine by helping ACh receptors accept or be more sensitive to acetylcholine, coluracetam enhances acetylcholine in a different way. It does this by affecting the high-affinity choline uptake (HACU) process of the brain’s neurons and boosting acetylcholine synthesis.

BCl-540, also known as Coluracetam powder, is a synthetic nootropic in the racetam family first developed by Mitsubishi Tanabe Pharma Corporation and later sold to Brain Cells Inc. It is a pyrrolidine compound with an additional 3-ring substituted fluoroquinolone component. Like other racetams, it affects AMPA receptors and has cholinergic activity. It has been shown to improve HACU and increase acetylcholine synthesis, which is important for memory formation.

Suitable for Schizophrenia

While some nootropics can trigger psychotic episodes in people with schizophrenia, coluracetam is different. It is a fat-soluble nootropic that works as an anxiolytic and helps with cognitive enhancement without the usual stimulant side effects. It enhances long-term and working memory, reduces depression, anxiety, and improves color and sound perception. It also increases the activity of acetylcholine-producing enzymes in brain cells.

The primary mechanism of coluracetam is its ability to boost choline uptake in neurons by increasing the high affinity choline transporter molecule CHT1. This makes the acetylcholine production in brains more efficient and leads to improved cognitive functions.

The supplement is available in a variety of forms including capsules and powder. It is best taken with a choline source like CDP-Choline or Alpha GPC to maximize absorption and minimize the possible side effects. It is expensive but gram for gram it is more potent than other racetams and offers unique neuroprotective properties. It is manufactured by Mitsubishi Tanabe Pharmaceutical Corporation in Japan and licensed to BrainCells Inc.

Suitable for Depression and Anxiety

Coluracetam (BCI-540, MKC-231) is a fat-soluble nootropic in the racetam class and is significantly more potent than Piracetam. It boosts brain choline conversion to acetylcholine, improving memory and cognition. It also enhances AMPA potentiation and has anxiolytic effects without affecting serotonin levels.

Some nootropic users report that it improves their mood and a feeling of well-being. It also increases alertness and makes them more focused. It is a non-toxic nootropic, with very few side effects, even at high doses. It is important to cycle this nootropic to avoid tolerance build-up and keep the effects strong.

One study on humans found that a dosage of up to 240 mg per day taken thrice was useful in relieving major depressive disorder and anxiety without causing any serious side effects. This is a relatively large dose compared to other racetams.